[October 9, 2018: Minneapolis, MN] Emerging medical device firm AdvancedCPR Solutions (formerly Minnesota Resuscitation Solutions) has received notification from the U.S. Patent and Trademark Office (USPTO) that the company’s broad method patent for ElevatedCPR therapy, which is exclusively licensed to the company, has been issued (Patent number 10092481). ElevatedCPR therapy is intended to help improve outcomes after cardiac arrest, one of the leading causes of death worldwide, by positioning the head and thorax to optimize circulation to the brain and heart during cardiopulmonary resuscitation (CPR).

ElevatedCPR therapy, also called head up or gravity assisted CPR, is a method for performing CPR while the head, heart and shoulders of the patient are lifted in a multi-angled incline.  This positioning allows the body to drain venous blood from the brain while CPR is being performed; and evidence shows a number of benefits associated with this positioning relative to intracranial pressure (ICP), cerebral perfusion pressure (CPP) and coronary perfusion pressure (COPP). ElevatedCPR therapy is intended to be used with a bundle of care including active compression-decompression CPR devices and an impedance threshold device (ITD) to help regulate the intrathoracic pressure while CPR is being performed.

Initial studies exploring ElevatedCPR therapy as part of this bundle of care have shown a strong potential to improve resuscitation and survival from sudden cardiac arrest.  Pre-clinical studies have shown doubled blood flow to and through the brain and other vital organs compared to today’s best-of-class CPR techniques and devices.[1] In addition, when compared to circulation from hands-only CPR with the patient supine or head flat, the increase in cerebral circulation is profound, nearly 4-fold after 15 minutes of CPR.[2] ElevatedCPR therapy also produces an immediate and significant reduction in intracranial pressure.²

The company’s initial device, the EleGARD Patient Positioning System (“EleGARD,” formerly MRS 525 Patient Positioning System), delivers precise patient positioning for the execution of high quality ElevatedCPR therapy in the pre-hospital and hospital setting. The EleGARD will be commercially available in 2019.

Founded in Minneapolis, Minnesota as Minnesota Resuscitation Solutions in 2015, AdvancedCPR Solutions is an early stage medical device firm focused on the development and commercialization of ElevatedCPR therapy delivery mechanisms, methods and devices to potentially improve survival of cardiac arrest.

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[1] Moore J, Segal N, Lick M, Dodd K, et al. Head and thorax elevation during active compression decompression cardiopulmonary resuscitation with an impedance threshold device improves cerebral perfusion in a swine model of prolonged cardiac arrest. Resuscitation. 2017;2017(121):195-200. doi: http://dx.doi.org/10.1016/j.resuscitation.2017.07.033.

[2] Moore J, Holley J, Segal N, Lick M. et al. Consistent head up cardiopulmonary resuscitation haemodynamics are observed across porcine and human cadaver translational models. Resuscitation. 2018;  https://doi.org/10.1016/j.resuscitation.2018.04.009