Poster Presentations at American Heart Association’s Resuscitation Science Symposium Demonstrate Improved Survival, Improved Cerebral Perfusion Pressure with Controlled Sequential Elevation

[November 18, 2019 Minneapolis, MN] Two posters presented this weekend at the American Heart Association’s Resuscitation Science Symposium demonstrate the benefits of device assisted head up CPR using controlled sequential elevation, which is a hallmark of AdvancedCPR Solutions’ ElevatedCPR® Method.

  • Controlled Sequential Elevation of the Head and Thorax Rapidly Achieves 50% of Baseline Cerebral Perfusion Pressure During Active Compression-Decompression Cardiopulmonary Resuscitation With an Impedance Threshold Device in a Swine Model of Cardiac Arrest, by Carolina Rojas-Salvador, was presented on November 16. The animal study set out to determine the optimal controlled sequence of elevation (CSE) to achieve a 50 percent baseline Cerebral Perfusion Pressure (CerPP) with active compression-decompression CPR and an impedance threshold device. The study compared a 4-minute elevation sequence to 10-minute elevation sequence, all with 2 minutes of “priming” prior to initiating elevation. Based on the results of the initial test, additional animals were studied with an elevation sequence of two minutes preceded by two minutes of priming, and a fourth group with a 24 second elevation and no priming. The presenter concluded “A 50% BL CerPP value was achieved in <3 minutes by combining a priming step and 2-min CSE time together with ACD+ITD CPR. This optimized approach is more advantageous than the 24-sec or 10-min elevation.”
  • Controlled Sequential Elevation of the Head and Thorax Combined With Active Compression Decompression Cardiopulmonary Resuscitation and an Impedance Threshold Device Improves Neurological Survival in a Swine Model of Cardiac Arrest, by Johanna C. Moore, was presented on November 17. The study hypothesized that active compression-decompression CPR (ACD-CPR) and an impedance threshold device (ITD) with controlled sequential elevation of the head and thorax (CSE) could increase neurologically intact survival when compared to conventional (C) CPR in the flat position. The study compared survival (measured by return of spontaneous circulation) and neurologically-intact outcomes (measured by a CPC score of 1-2) in animals receiving standard flat CPR and CPR using a controlled elevation sequence of two minutes of priming in the lowest position and a two minute elevation combined with ACD-CPR and an ITD. Eight of eight (100%) animals who received controlled sequential elevation with ACD-CPR and ITD achieved ROSC and six of eight (75%) were determined to be neurologically intact. In the standard CPR group, only two of eight (25%) animals achieved ROSC and only one of eight (12.5%) was determined to be neurologically intact. The presenter concluded that “The novel bundled resuscitation approach of CSE with ACD+ITD CPR increased neurologically intact survival 6-fold versus C-CPR in a swine model of cardiac arrest.”

AdvancedCPR Solutions’ ElevatedCPR method is a broad, patent-protected and technologically-advanced technique for performing device-assisted head up CPR that incorporates raising the head, heart, and thorax in a multi-level elevation, in a timed sequence, in conjunction with the best practice standards of resuscitation protocols. Preclinical studies have demonstrated a number of benefits associated with the ElevatedCPR method relative to intracranial pressure (ICP),1 2 3 cerebral perfusion pressure (CerPP)1 2 3 4 5 6 7 and coronary perfusion pressure (CorPP).2 3 4 5 6 7

The company’s initial device, the EleGARDTM Patient Positioning System, is intended to assist in controlled elevation of the head and thorax of a patient from a supine position into a multi-level elevated position with the head above the thorax and the thorax above the lower body and extremities, and may be used for airway management procedures and CPR. It is the only device that precisely, rapidly, and consistently positions patients for the practice of the ElevatedCPR method in the pre-hospital and hospital settings.

Founded in Minneapolis, Minnesota in 2015 by an experienced team that previously developed multiple novel resuscitation technologies currently in widespread clinical practice, AdvancedCPR Solutions is an early stage medical device firm focused on the development and commercialization of delivery mechanisms, methods and devices that enable the ElevatedCPR method to potentially improve survival of cardiac arrest.  The company’s first device, the EleGARD Patient Positioning System, was launched for use in the US earlier this year.

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1 Debaty, Resuscitation 2015; 2 Ryu, Resuscitation 2016; 3 Moore, Resuscitation 2018; 4 Kim, Resuscitation, 2017; 5 Moore, Circulation 2018; 6 Rojas, NAEMSP 2019; 7 Frascone, Gathering of Eagles 2019