[January 11, 2019: Minneapolis, MN] A poster presented at the National Association of EMS Physicians (NAEMSP) shows that emerging medical device firm AdvancedCPR Solutions’ novel method of ElevatedCPR therapy using controlled elevation of the head, heart and thorax in a timed sequence improves cerebral perfusion pressure (CerPP) in an animal model.  The poster, Controlled Head and Upper Thorax Elevation Improves Cerebral Perfusion Pressure during Active Compression-Decompression Cardiopulmonary Resuscitation (ACD-CPR) with an Impedance Threshold Device (ITD) in a Porcine Model of Cardiac Arrest, was presented January 10 by Carolina Rojas-Salvador MD at NAEMSP’s annual Congress in Austin, Texas.

The poster study evaluated whether an elevation rate of 3 centimeters per minute over 4 minutes would result in higher cerebral perfusion pressure compared to an elevation rate of 1.2 centimeters per minute over 10 minutes during a total of 19 minutes of CPR with active compression decompression and an impedance threshold device (ACD+ITD CPR). Using a novel head and upper thorax elevation device (the EleGARD^TM Patient Positioning Device by AdvancedCPR Solutions) and elevation sequence to regulate the height and elevation time, the study concluded that significantly higher CerPP was achieved at 7 minutes in the 3 cm/min group versus the 1.2 cm/min group. These values were preserved over time, and CerPP and Coronary Perfusion Pressure (CorPP) values were greater than 70% of baseline after 19 minutes of CPR without exogenous vasopressors.

The authors concluded, “This novel approach has the potential to significantly improve vital organ blood flow during CPR.”

ElevatedCPR therapy is a technologically-advanced method of performing device-assisted head up CPR that incorporates lifting the head, heart, and thorax in a multi-angled incline, in a timed sequence, in conjunction with the best practice resuscitation protocols. ElevatedCPR therapy is intended to be used with a bundle of care optimally including manual or automated active compression-decompression CPR devices and an impedance threshold device to help regulate the intrathoracic pressure while CPR is being performed.

Initial studies exploring ElevatedCPR therapy as part of this bundle of care have shown a strong potential to improve elements of successful resuscitation that could lead to survival from sudden cardiac arrest.  Pre-clinical studies have shown doubled blood flow to and through the brain and other vital organs compared to today’s best-of-class CPR techniques and devices.[1]In addition, when compared to circulation from hands-only CPR with the patient supine or head flat, the increase in cerebral circulation is profound, nearly 4-fold after 15 minutes of CPR.[2] ElevatedCPR therapy also produces an immediate and significant reduction in intracranial pressure.²

The company’s initial device, the EleGARD Patient Positioning System delivers precise patient positioning for the execution of high quality ElevatedCPR therapy in the pre-hospital and hospital setting. The EleGARD will be commercially available in 2019.

Founded in Minneapolis, Minnesota in 2015 by an experienced team that previously developed multiple novel resuscitation technologies currently in widespread clinical practice, AdvancedCPR Solutions (formerly Minnesota Resuscitation Solutions) is an early stage medical device firm focused on the development and commercialization of ElevatedCPR therapy delivery mechanisms, methods and devices to potentially improve survival of cardiac arrest.

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[1] Moore J, Segal N, Lick M, Dodd K, et al. Head and thorax elevation during active compression decompression cardiopulmonary resuscitation with an impedance threshold device improves cerebral perfusion in a swine model of prolonged cardiac arrest. Resuscitation. 2017;2017(121):195-200. doi: http://dx.doi.org/10.1016/j.resuscitation.2017.07.033.

[2] Moore J, Holley J, Segal N, Lick M. et al. Consistent head up cardiopulmonary resuscitation haemodynamics are observed across porcine and human cadaver translational models. Resuscitation. 2018;  https://doi.org/10.1016/j.resuscitation.2018.04.009